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Sunday, February 5, 2012
Hollywood Casino at Kansas Speedway Waves the Green Flag on ...
[unable to retrieve full-text content]?As the first new casino in the Kansas City market in 15 years, Hollywood Casino at Kansas Speedway offers guests a state-of-the-art destination with premier gaming, dining and entertainment options,? commented Peter ...
Saturday, February 4, 2012
New Beacon Hill Homes in Seattle For Sale Update 2/3/2012 ...
Showing properties
1 - 5 of 48.
See more Beacon Hill community real estate.
(all data current as of
2/3/2012)
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3 beds, 1 full, 1 part baths
Home size: 1,610 sq ft
Lot size: 5,950 sq ft
Year built: 1982
Parking spots: 1
Days on market: 2
Walk Score?: 74
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3 beds, 1 full bath
Home size: 1,540 sq ft
Lot size: 7,357 sq ft
Year built: 1954
Parking spots: 1
Days on market: 2
Walk Score?: 68
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2 beds, 2 full baths
Home size: 1,100 sq ft
Year built: 2011
Days on market: 3
Walk Score?: 54
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2 beds, 1 full bath
Home size: 900 sq ft
Lot size: 5,046 sq ft
Year built: 1941
Parking spots: 1
Days on market: 3
Walk Score?: 63
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2 beds, 1 full, 1 part baths
Home size: 1,280 sq ft
Year built: 2007
Parking spots: 1
Days on market: 4
Walk Score?: 69
Listing information deemed reliable but not guaranteed. Read full disclaimer.
Post by Thach Nguyen
Thach Nguyen is the Founder and CEO of Thach Real Estate Group, company that serves people from diverse cultures and communities in buying, selling and investing in real estate.
Thach has written 1964 articles.
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Friday, February 3, 2012
UN council envoys gather to discuss Syria (AP)
UNITED NATIONS ? Ambassadors to the U.N. Security Council gathered behind closed doors Wednesday in hopes of hammering out language they can all accept in a resolution on Syria.
Envoys heading into the afternoon session made clear they still disagreed on some key issues, especially the current draft's call for Syrian President Bashar Assad to step aside.
Indian Ambassador Hardeep Singh Puri said the text needed to state clearly that armed opponents, as well as Assad's security forces, were responsible for the continuing bloodshed in Syria.
As to the demand that Assad leave power, Puri said: "How (do you) get both sides to agree if the precondition for one side is to step down?"
Portuguese Ambassador Jose Filipe Moraes Cabral said he believed that "good conditions" exist for consensus. With more lives and the possibility of civil war in the balance "there are too many things at stake for us not to arrive at a reasonable compromise," Cabral said.
Russian officials have said they'll oppose the resolution if it contains any hint of a military intervention or regime change in Syria, a major ally.
Russian Ambassador Vitaly Churkin told reporters before Wednesday's session that a change in the current language calling for Assad to step aside "would make it easier for us" to approve.
On Tuesday, Secretary of State Hillary Rodham Clinton and the foreign ministers of Britain and France joined Arab League officials in a high-level meeting at the U.N. urging council members to approve the resolution.
Clinton reiterated Wednesday that it was important for the council to move quickly.
"Every member of the council has to make a decision, whose side are you on? Are you on the side of the Syrian people ... or are you on the side of a brutal dictatorial regime?" she said.
Clinton has said she will discuss the resolution with her Russian counterpart Sergei Lavrov at the Munich Security Conference in Germany this weekend.
Amnesty International called on Russia to stop what it said was its "unconscionable" obstruction of U.N. efforts to help end the bloodshed in Syria. The U.N. said several weeks ago that at least 5,400 people have been killed in the 10-month-old government crackdown on a civilian uprising.
Russia and China used a double veto in October to block an earlier Security Council resolution condemning the violence in Syria.
"Russia's threats to abort a binding U.N. Security Council resolution on Syria for the second time are utterly irresponsible," Jose Luis Diaz, Amnesty International's U.N. representative, said Wednesday.
"Russia bears a heavy responsibility for allowing the brutal crackdown on legitimate dissent in Syria to continue unchecked," he said.
Diaz noted that Russia is the Syrian government's largest overseas arms supplier and reportedly has continued arms shipments to the country in recent weeks.
Martin Nesirky, the spokesman for the U.N. secretary-general, said Wednesday that Ban Ki-moon hopes the international community, and the Security Council in particular, will respond to the violence in Syria with "a unified voice."
"He's concerned that as time passes more people are being killed," Nesirky said. "The need for action is because of the need to stop the killing."
___
Associated Press writers Eileen Alt Powell at the United Nations and Bradley Klapper in Washington contributed to this report.
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Interesting Ideas And Insights For Home Based Business
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By: Legget Mcquerry
Supplies for your business can procured at remarkable discounts online. Online shopping will reveal a mass amount of product with competitive pricing for the purchase of this kind of product. You can buy supplies this way using your business license.
Select a moniker that has a meaning. Your name should be representative of what you sell, which is why it is important to have a name that customers can appreicate. The name you choose could have a memorable or interesting connotation. That way, you will develop a focused branding strategy that will engender goodwill among buyers.
Promote your business online. Either by yourself or through a professional designer, have an easily navigable website constructed for your customers. Your website should have content that is relevant to those who visit your site while also making it easy for users to interact with the services you want them to use, such as your web store. Continue to fine tune and investigate new ways to make your website a successful marketing tool for your company.
Daycare home business require sufficient help. Without the extra help, normal tasks, such as feeding the kids, getting them to nap and keeping them out of trouble will be much more difficult.
As you have just learned, there are many people trying to sell you on scams. However, as you've learned throughout this article, there are also many common-sense tips and tactics that you can use in order to grow your home business. If you're willing to put in the work, you can certainly be successful.
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Thursday, February 2, 2012
Ancient DNA holds clues to climate change adaptation
Tuesday, January 31, 2012
Thirty-thousand-year-old bison bones discovered in permafrost at a Canadian goldmine are helping scientists unravel the mystery about how animals adapt to rapid environmental change.
The bones play a key role in a world-first study, led by University of Adelaide researchers, which analyses special genetic modifications that turn genes on and off, without altering the DNA sequence itself. These 'epigenetic' changes can occur rapidly between generations ? without requiring the time for standard evolutionary processes.
Such epigenetic modifications could explain how animal species are able to respond to rapid climate change.
In a collaboration between the University of Adelaide's Australian Centre for Ancient DNA (ACAD) and Sydney's Victor Chang Cardiac Research Institute, researchers have shown that it is possible to accurately measure epigenetic modifications in extinct animals and populations.
The team of researchers measured epigenetic modifications in 30,000-year-old permafrost bones from the Yukon region in Canada, and compared them to those in modern-day cattle, and a 30-year-old mummified cow from New Zealand.
Project leader Professor Alan Cooper, Director of ACAD, says: "Epigenetics is challenging some of our standard views of evolutionary adaptation, and the way we think about how animals use and inherit their DNA. In theory, such systems would be invaluable for a wide range of rapid evolutionary adaptation but it has not been possible to measure how or whether they are used in nature, or over evolutionary timescales."
Epigenetics specialist and co-investigator Dr Catherine Suter, from the Victor Chang Institute, has been studying the role of epigenetics in adaptation in laboratory animals. She jumped at the chance to test epigenetic methods in ancient DNA, which had never previously been attempted.
"This is the first step towards testing the idea that epigenetics has driven evolution in natural populations," Dr Suter says.
Professor Cooper says: "The climate record shows that very rapid change has been a persistent feature of the recent past, and organisms would need to adapt to these changes in their environment equally quickly. Standard mutation and selection processes are likely to be too slow in many of these situations."
"Standard genetic tests do not detect epigenetic changes, because the actual DNA sequence is the same," says lead author, ACAD senior researcher Bastien Llamas, an Australian Research Council (ARC) Fellow. "However, we were able to use special methods to show that epigenetic sites in this extinct species were comparable to modern cattle.
"There is growing interest in the potential evolutionary role of epigenetic changes, but to truly demonstrate this will require studies of past populations as they experience major environmental changes," he says.
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This work has been published in the online peer-reviewed journal PLoS ONE.
University of Adelaide: http://www.adelaide.edu.au
Thanks to University of Adelaide for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/117209/Ancient_DNA_holds_clues_to_climate_change_adaptation
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Wednesday, February 1, 2012
Researchers indentify a cell-permeable peptide that inhibits hepatitis C
Tuesday, January 31, 2012
Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a cell-permeable peptide that inhibits a hepatitis C virus protein and blocks viral replication, which can lead to liver cancer and cirrhosis.
This finding by Dr. Samuel French, an assistant professor of pathology and senior author of the study, builds on previous work by the French laboratory that identified two cellular proteins that are important factors in hepatitis C virus infection.
French and his team initially set out to identify the cellular factors involved in hepatitis C replication and, using mass spectrometry, found that heat shock proteins (HSPs) 40 and 70 were important for viral infection. HSP70 was previously known to be involved, but HSP40 was linked for the first time to hepatitis C infection, French said. They further showed that the natural compound Quercetin, which inhibits the synthesis of these proteins, significantly inhibits viral infection in tissue culture.
In this study, published Jan. 30, 2012 in the peer-reviewed journal Hepatology, French and his team demonstrated that the viral non-structural protein 5A (NS5A) directly binds to HSP70 and mapped the site of the NS5A/HSP70 complex on NS5A. While HSP70 was previously shown to bind NS5A in cells, a direct NS5A/HSP70 interaction and complex formation was established in this study. In an effort to stop this interaction, they tested peptides that might inhibit HSP70.
"This is important because we've developed a small peptide that binds to that site and blocks the interaction between the proteins that is important for viral replication," French said. "This is another, potentially highly efficacious way to block replication of hepatitis C."
An estimated 160 million people worldwide are infected with hepatitis C and the conventional treatments ? interferon and ribavirin ? can have significant side effects. A new drug targeting cellular proteins rather than viral proteins would be a valuable addition to the treatment arsenal, French said.
"We were surprised that this peptide works this well," French said. "While its mechanism is different, the activity of this peptide is comparable to other newly developed anti-virals."
The study, done in tissue culture, shows that the peptide gains entry into the cell easily and blocks the cascade of cellular events that allows the virus to replicate, French said. Blocking the HSP70 protein rather than a viral protein also reduces the chance of patients with the hepatitis C virus developing resistance to the peptide.
"There's no direct pressure on the virus, so it is less likely to mutate and develop resistance," French said. "The goal is to achieve a sustained response, essentially a cure, meaning there is no more virus replication. There are a lot of drugs coming out now that are designed to stop hepatitis C replication, but resistance is still an issue. About 10 to 20 percent of patients on the new drugs become resistant. This new peptide may help combat resistance."
Going forward, French and his team are testing variants of the newly discovered peptide to see if they can develop one with an even higher affinity and can decrease the size of the peptide to improve cellular penetration and liver targeting. The new and improved peptides will be tested in animal models.
This peptide "may be a candidate for hepatitis C therapy," the study states. "Considering the potency of the peptide in suppressing viral translation levels, treatment with this peptide may significantly improve the efficacy of conventional treatments in patients who become resistant to conventional therapies."
###
University of California - Los Angeles Health Sciences: http://www.uclahealth.org/
Thanks to University of California - Los Angeles Health Sciences for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
This press release has been viewed 60 time(s).
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Japanese auto suppliers to pay price-fixing fine
WASHINGTON (AP) ? Two Japanese auto suppliers have agreed to pay more than half a billion dollars in criminal fines for a price-fixing conspiracy in the sale of parts to U.S. automakers, the Justice Department announced Monday.
Yazaki Corp. agreed to pay a $470 million fine, the second-largest criminal fine obtained for an antitrust violation. The second company, DENSO Corp., agreed to pay a $78 million fine. Four Yazaki executives, all Japanese citizens, will serve up to two years in U.S. prison as part of the deal to plead guilty to one felony count.
The pleas are part of an ongoing investigation that is the largest ever in the Justice Department antitrust division. Sharis Pozen, the division's acting head, told reporters in a briefing that "pernicious cartel conduct" in the auto parts industry has harmed car buyers and auto manufacturing businesses nationwide. "The numbers that we are talking about here are astronomical," she said.
Court documents filed in federal court in Detroit say the Japanese companies and executives sold automotive electrical components to automakers in the United States and elsewhere at inflated prices. The Justice Department says they met to monitor and enforce adherence to the bid-rigging and price-fixing scheme from at least January 2000 through February 2010.
"This criminal activity has a significant impact on the automotive manufacturers in the United States, Canada, Japan and Europe and had been occurring at least a decade," the FBI's Special Agent in Charge Andrew Arena said in a statement. "The conduct had also affected commerce on a global scale in almost every market where automobiles are manufactured and/or sold."
The Justice Department would not comment on which automakers were affected by the conspiracy, how many models were affected and how much the price-fixing scheme inflated vehicle prices because the investigation continues. But Pozen said there's no doubt consumers were hurt financially.
Prosecutors say Yazaki's bid rigging included automotive wire harnesses used to direct and control a vehicle's electronic components, instrument panel clusters that drivers use on the dashboard to gauge vehicle performance and fuel senders that measure the amount of gas in the tank. DENSO's alleged price-fixing involved electronic control units that control electronic systems and heater control panels that control temperature inside the vehicle from the center console.
It's almost impossible to calculate how much more automakers had to pay for the parts, said Jim Gillette, an analyst with the firm IHS Automotive. But the scheme likely drove up costs for consumers since the prices were illegally fixed on expensive electrical parts and have risen in cost as cars have become more complex in recent years, he said.
Gillette estimated that price-fixing of wiring harnesses alone cost carmakers hundreds of millions of dollars. Climate control units are even more expensive because they have become more than just dials and switches in recent years. Even entry-level cars have digital controls that allow drivers and passengers to set their own temperatures, he said.
The two-year sentences against the executives would be the longest term of imprisonment ever imposed on a foreign national voluntarily submitting to U.S. jurisdiction for a Sherman Act antitrust violation, the Justice Department said.
The executives are Tsuneaki Hanamura, a branch manager at Yazaki North America in Columbus, Ohio, and a Honda division sales manager in Japan; Ryoji Kawai, director of Toyota Sales of Yazaki North America in Lexington, Kentucky, and vice division head of Yazaki's Toyota Business Unit in Japan; Shigeru Ogawa, assistant section manager and later section manager in Yazaki's Honda Business Unit in Japan and branch manager in Yazaki's Honda Sales Unit and later director at Yazaki North America in Columbus; and Hisamitsu Takada, assistant manager in Yazaki's Toyota Business Unit, director of Yazaki North America in Lexington, and manager of a sales department of Yazaki's Toyota Business Unit in Japan.
Hanamura and Kawai have each agreed to serve two years, and Ogawa and Takada have each agreed to serve 15 months. Each of the four has also agreed to pay a $20,000 criminal fine.
In November, Furukawa Electric Co. Ltd. pleaded guilty and was sentenced to pay a $200 million fine for its role in the wire harnesses price-fixing and bid-rigging conspiracy. Three Furukawa executives also pleaded guilty and serve prison terms in the United States.
The largest fine in antitrust history was $500 million in 1999 against Swiss drug company F. Hoffmann-La Roche Ltd. for leading a worldwide conspiracy to raise and fix prices for vitamins.
___
AP Auto Writer Tom Krisher in Detroit contributed to this report.
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